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High-density lipoproteins carry excess cholesterol to the liver for elimination, but recent research suggests that "good cholesterol" may also act as a special transport vehicle for destruction for cancer.
Synthetic HDL nanoparticles loaded with small interfering RNA to silence cancer-promoting genes selectively reduced or destroyed ovarian cancer tumors in mice, reported a research team led by scientists at the MD Anderson Cancer Center of The University of Texas and the University of North Texas Health Science Center in the April issue of Neoplasia ("Targeted Delivery of Small Interfering RNA Using Reconstituted High-Density Lipoprotein Nanoparticles").
According to scientists, the next step is to prepare for human clinical trials. "If we are able to knock out 70, 80 or 90 percent of tumors without the drug accumulating in the normal tissues of mice, it is likely that many cancer patients can benefit from this new type of treatment in the long term. ”.