Prostate cancer

Is prostate cancer inherited?

Is prostate cancer inherited?

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Having a close relative with prostate cancer can double the relative risk

It is estimated that around 5-10% of prostate cancers are linked to genes.

There is no single specific gene responsible for prostate cancer. Studies suggest that the combination of variations in certain genes could be involved.

Each variation has only a very small effect on prostate cancer risk, but men who have inherited several of these genetic variations may have a significantly higher risk of developing prostate cancer.

Genes associated with prostate cancer

Along with age, family history is one of the most important risk factors for prostate cancer.

Between 5 and 10% of all diagnosed prostate cancers are hereditary.

In recent years, studies have identified a number of inherited genetic changes that can contribute to the risk of developing prostate cancer in a man. New research suggests that men with mutations in the BRCA1 and BRCA2 genes, the same genes that have been associated with breast and ovarian cancer, are at increased risk of developing prostate cancer.

A man with a genetic defect in the BRCA2 gene has almost 4 times the risk of developing prostate cancer than men in the general population. Additionally, male prostate cancers carrying BRCA2 gene mutations also tend to be more aggressive.

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Video: Prostate Cancer Genetics 101 (August 2022).